Herman Ray
Kennesaw State University, USA
Title: Unbiased estimation after phase II clinical trials involving multiple endpoints
Biography
Biography: Herman Ray
Abstract
The single arm, two-stage clinical trial design is a popular methodology to evaluate oncology treatments in the phase II setting. The designs are typically augmented with an ad hoc toxicity monitoring rule which is imposed outside of the formal two-stage design but there are also several designs that formally incorporate both endpoints simultaneously. There are many problems that prevent the designs from being used in practice which includes point estimation after the execution of the study. We will examine an unbiased estimator that accounts for both endpoints simultaneously along with the correlation between the endpoints. The behavior of the estimate is examined through simulation studies. It is compared to the maximum likelihood estimator